Cancers are, without a doubt, quite challenging. And, there is no doubt that brain tumors, and those cancers that spread to the brain, are among the biggest challenges in oncology. This, however, doesn’t mean that scientists are losing hope and pretty much giving up on researching them, and just leaving things be. Quite on the contrary, they are working as hard as possible to discover new overcome certain challenges, and to ultimately develop better treatments for patients.
One of the reasons why brain tumors are so difficult to treat is because there is something called the blood-brain barrier, or BBB. You can visit this page to better understand what it is and what its function is in general. When it comes to tumors, this is basically a natural defense that prevents a lot of drugs from actually reaching those cancer cells inside the brain. You can understand, thus, how big of a challenge it can be, and why it is that some brain cancers wind up being resistant to treatment, due to the drugs not being able to reach the brain at all.
Furthermore, you can guess right away that this is one of the biggest challenges that scientists are trying to overcome when it comes to oncology, and that BBB is, therefore, being thoroughly researched. So, they have been designing molecules that not only target specific cancer signaling pathways, but that can also break the blood-brain barrier and penetrate it. And, well, Paxalisib (GDC-0084) PI3K/mTOR Inhibitor appears to be one of those drugs, acting as a dual inhibitor, and designed to cross that barrier and act against those tumors that depend on PI3K/mTOR signaling.
It is no wonder, therefore, that this particular drug has been driving a lot of attention in recent years, especially in the study of glioblastoma and brain metastasis. What we are going to do in this article, thus, is explore this drug in a bit more details, helping you understand what it is and how it works, as well as taking you through the steps necessary if you want to obtain it for research purposes yourself. So, without any further ado, let us dive right into the topic.
What Is Paxalisib (GDC-0084) PI3K/mTOR Inhibitor?
Unsurprisingly, we are going to begin with the topic of Paxalisib (GDC-0084) PI3K/mTOR Inhibitor specifically. That is, we are going to explain what this drug is, how it works, as well as what it is that is known about it so far. Understanding these basics is essential, whether you are a researcher, or just someone curious about the developments in the area of brain cancer treatments. And, if you’re a researcher, the basics can set the stage for your future studies and experiments, which is undeniably of crucial importance.
So, let us cut right to the chase. In the simplest words possible, Paxalisib (GDC-0084) PI3K/mTOR Inhibitor is a drug that acts as a dual inhibitor, affecting both PI3K and mTOR, in an effort to stop them from sending the signals that tell cells to survive, grow, divide, and proliferate. Now, inhibiting just one of these pathways may not be enough, since it can lead to compensatory feedback loops which actually reactivate parts of the pathway, which is why the dual inhibition mechanism of this drug is so important. This dual design is deliberate, and it aims at cutting off both the downstream and the upstream signal, which is extremely important for tumors that heavily depend on this specific axis.
Apart from this, you also have to know that Paxalisib (GDC-0084) PI3K/mTOR Inhibitor has actually been created with BBB in mind. To put it differently, it was developed with certain specific modifications that allow it to cross the blood-brain barrier, and thus be able to affect those cancer cells found in the brain. At the moment, it is being used in human clinical studies, administered orally, with the main focus of research being the central nervous system tumors, such as glioblastoma, as well as brain metastases, and even primary CNS lymphoma.
The results from the trials so far are quite encouraging. Put simply, Paxalisib (GDC-0084) PI3K/mTOR Inhibitor has shown to be able to do exactly what has been predicted. That is, to inhibit that axis that the tumors depend on, and to penetrate the blood-brain barrier, which is necessary if any kinds of effects are to be expected from the drug. And, while it has still not been approved, it is definitely used in active clinical development in those CNS cancer settings.
Where Can You Get It?
Moving on to our next question right now. If you are a researcher and you want to study Paxalisib (GDC-0084) PI3K/mTOR Inhibitor in your lab, you will have to, well, first get it somewhere. Of course, this is something that you should discuss with the actual institution, checking their requirements and getting the necessary permissions. But, if you’ve done all of that, or if you’re planning on doing it after you’ve found where you can buy this drug, and thus be prepared for the conversation, then it is not a surprise that you’re interested in better understanding where it is that you can actually find it.
And, well, the good news is that there are chemical suppliers out there catering to labs, and they will undeniably be ready to sell this substance to you. The even better news is that you can most likely find a lot of them online, and thus even place your order through the Internet, which makes things a lot easier. The only thing is, you should always keep in mind that not all suppliers are the same, and that you have to, therefore, do your research to carefully choose the right one for you.
So, get some recommendations or find them online. Then, check their legitimacy and reputation through, for example, reading some reviews. After that, remember to check the purity of the Paxalisib (GDC-0084) PI3K/mTOR Inhibitor they are selling, as well as for the necessary documentation that they need to provide. Finally, start with a small batch and evaluate it once it arrives, and if you’re happy, order more, and form a long-term partnership with the actual supplier you have chosen.